译者
王力群、拱忠影、薛萍、邱晓峰、
崔兴华、赵思佳、范秉林
文献审校：张慜
文献提供：林宏
李神经文献翻译中心出品
第一部分
AbstractMultifocalmotorneuropathy(MMN)isarareinflammatoryneuropathycharacterizedbyslowlyprogressive,asymmetricdistallimbweaknesswithoutsensoryloss.TheclinicalpresentationofMMNmaymimicamyotrophiclateralsclerosis,othervariantsofmotorneurondisease,orchronicinflammatorydemyelinatingpolyneuropathywithasymmetriconset.Differentiationisimportant,asthesediseasesdifferinprognosisandtreatment.TheelectrophysiologicalfindingofconductionblockintheabsenceofabnormalitiesinsensorynervesisthehallmarkofMMN,butcanbedifficulttodetect.Intravenousimmunoglobulinisefficaciousinmostpatients,butlong-termmaintenancetherapydoesnotpreventslowlyprogressiveaxonaldegeneration.Moreover,cyclophosphamide,althougheffective,hassubstantialadverseeffects,andtheefficacyofotherimmunosuppressivedrugs,includingrituximab,isnotestablished.TheunderlyingpathologicalmechanismsofMMNareunclear,butIgMautoantibodiesagainstthegangliosideGM1maycausechangesinnodalandperinodalstructuresthat南京白癜风专科医院石家庄最好的白癜风医院
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